The use of microbeams to investigate radiation damage in living cells

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The use of microbeams to investigate radiation damage in living cells.

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Cellular micro-irradiation using ion beams is now recognised as a highly versatile technique for understanding how ionising radiation interacts with living cells and tissues. The strength of the micro-irradiation technique lies in its ability to deliver precise doses of radiation to selected individual cells (or sub-cellular targets) in vitro. The application of this technique in the field of r...

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DNA damage and repair kinetics after microbeam radiation therapy emulation in living cells using monoenergetic synchrotron X-ray microbeams

A novel synchrotron-based approach, known as microbeam radiation therapy (MRT), currently shows considerable promise in increased tumour control and reduced normal tissue damage compared with conventional radiotherapy. Different microbeam widths and separations were investigated using a controlled cell culture system and monoenergetic (5.35 keV) synchrotron X-rays in order to gain further insig...

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ژورنال

عنوان ژورنال: Applied Radiation and Isotopes

سال: 2009

ISSN: 0969-8043

DOI: 10.1016/j.apradiso.2008.06.015